P-063: Thiopurine metabolite (TM) monitoring in paediatric IBD (PIBD): revolution of clinical practice
نویسندگان
چکیده
منابع مشابه
Role of thiopurine metabolite testing and thiopurine methyltransferase determination in pediatric IBD.
Thiopurines have been used in inflammatory bowel disease (IBD) for >30 years, and measurements of both thiopurine methyltransferase (TPMT) and thiopurine (TP) metabolites, 6-thioguanine nucleotides (6-TGN) and 6-methylmercaptopurine (6-MMP), have been readily available. The North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) Committee on Inflammatory Bowe...
متن کاملA practical guide to thiopurine prescribing and monitoring in IBD.
Thiopurines are often the mainstay of treatment for many patients with inflammatory bowel disease. As such, a general understanding of the evidence behind their use and of their metabolism is extremely useful in clinical practice. This review gives a practical overview of thiopurine metabolism, the importance of thiopurine S-methyltransferase testing prior to the start of therapy and the monito...
متن کاملTherapeutic drug monitoring of thiopurine metabolites in adult thiopurine tolerant IBD patients on maintenance therapy.
BACKGROUND AND AIMS Therapeutic drug monitoring of active metabolites of thiopurines, azathioprine and 6-mercaptopurine, is relatively new. The proposed therapeutic threshold level of the active 6-thioguanine nucleotides (6-TGN) is ≥235 pmol/8×10(8) erythrocytes. The aim of this prospective cross-sectional study was to compare 6-TGN levels in adult thiopurine tolerant IBD patients with an exace...
متن کاملDrug level monitoring in paediatric practice.
A knowledge of the concentration of a drug in blood or other tissue fluid is now considered an important and sometimes essential part of the therapeutic management of various conditions. Its importance has increased as information showing wide interindividual variation in drug response has become recognised. Such variation arising from differences in absorption, distribution, and elimination ap...
متن کاملAllopurinol in combination with thiopurine induces mucosal healing and improves clinical and metabolic outcomes in IBD
Background Thiopurines, azathioprine (AZA) and 6-mercaptopurine (6-MP) are common maintenance medications for inflammatory bowel disease (IBD). Excessive methylation via thiopurine methyltransferase (TPMT) frequently causes therapeutic failure. Allopurinol reduces excessive 6-methyl-mercaptopurine (6-MMP) while enhancing 6-thioguanine (6-TGN) levels. The aim of this study was to evaluate clinic...
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ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis
سال: 2014
ISSN: 1873-9946
DOI: 10.1016/s1873-9946(14)50080-3